BIOCOMPATIBILIDAD DEL FOSFATO TRICALCICO CON QUITOSANO PARA USO EN REGENERACION OSEA
Artículo de Investigación
2015-07-01
Temáticas
BIOCOMPATIBILITY
BIOMATERIALES
It is necessary to develop bone grafts capable to regenerate critical size bone defects. Objective: To evaluate the biocompatibility in vivo of tricalcium phosphate with chitosan (TPC) in skin, muscle, and bone. Methods: 15 Wistar rats were assigned to groups A (skin), B (muscle), C, D, and E (bone). TPC was placed in each tissue. In groups C-E, critical size bone defect was grafted with TPC and collagen sponge was placed adjacent to test sites as a control. Animals from groups A and B were sacrificed after 20 days, while groups C-E at days 45, 60, and 80. Inflammatory response was evaluated in all tissues. To assess biocompatibility, the percentage of cells was evaluated as none (0 %), low (˂ 30 %), moderate (30- 50 %), and high (˃50 %). Results: There were no signals of ulceration or suppuration in skin, muscle, and bone. After 80 days, TPC was incorporated into a fibrotic structure and osseointegrated to native bone
Nombre Comercial
Biocompatibility of tricalcium phosphate with chitosan for bone regeneration purposes
Idioma
Español
Fecha Publicación
2015-07-01
País
COLOMBIA
Ciudad
Bogota
Vólumen
34
Número
73
Página Inicial
1
Página Final
14
Total Páginas
13
Dspace
2dea3eee-6e1e-42f1-a417-a09db907751e
Handle
http://red.uao.edu.co//handle/10614/12168
Sicti
2852
DOI
10.11144/Javeriana.uo34-73.bftq
RDI: Repositorio Digital
https://red.uao.edu.co/entities/publication/2dea3eee-6e1e-42f1-a417-a09db907751e
Doi
https://doi.org/10.11144/Javeriana.uo34-73.bftq